Jay and Silent Bob (Jason Mewes and Kevin Smith) lose a court case to Saban Films, who are making a new Bluntman and Chronic film, Bluntman V Chronic. They also unknowingly gave up naming rights, and can no longer call themselves “Jay and Silent Bob”.
Jay and Bob visit Brodie Bruce (Jason Lee), who tells them about the Bluntman and Chronic reboot, directed by Kevin Smith. Largely completed, but a major scene is to be shot at the annual fan convention “Chronic-Con” in Hollywood. They have three days to get to Los Angeles to stop film completion and win back their identities.
Departing for California, they first arrive in Chicago, where Jay sees his ex Justice (Shannon Elizabeth) is a local weatherperson. Jay and Bob visit Justice, who tells Jay he left her heartbroken by never visiting her in jail. She has since married Reggie (Rosario Dawson) and given birth to their love child, Millennium “Milly” Faulken (Harley Quinn Smith). Introducing Jay to their daughter and her best friend Sopapilla (Treshelle Edmond), but urges him to never tell her who he is.
Justice leaves for vacation, and Milly forces Jay to take her and Sopapilla to Hollywood with them. Drugging Jay and Bob with a strong edible, they wake up on a highway in New Orleans, where they meet Milly’s two other friends, Jihad (Aparna Brielle) and Shan Yu (Alice Wen). Saying they want to go to Chronic-Con as Shan Yu is a huge fan of the first film and it is her dream to attend. Stealing a van, they drive to California. Milly blames her bad behavior on never knowing her dad.