In Pittsburgh, a woman named Amanda Cooper falls ill with a rare form of cancer. Her husband, survival expert Ray Cooper, is told that a potentially life saving drug for Amanda was pulled off the market days before her treatment was set to begin, due to BioPrime CEO Simon Keeley paying the manufacturer to delay production. Watching Keeley on a live debate with Congresswoman Diana Morgan, Ray calls in and threatens Keeley, saying if he doesn’t reverse his decision, he’ll kill him. Keeley doesn’t take the threat seriously and Amanda passes away soon after, devastating Ray and their daughter, Rachel.
Six months later, Ray receives a call from a journalist, Martin Bennett, who tells him that he has evidence of criminal activity committed by BioPrime. They meet on a subway, unknowingly followed by Rachel and a hitman named Santos. Bennett explains that BioPrime has been bribing anyone who questions their dirty deeds, but before he can share his information, Santos stabs him dead. As the train stops at a station, Santos stabs Ray and knocks out Rachel, leaving them both on the platform for dead. Two years later, Ray and Rachel have been obsessively tracking Keeley’s movements. Ray poses as a waiter to infiltrate BioPrime’s charity auction so he can interrogate Keeley. Keeley says he knows nothing and tells him to go after BioPrime’s chairman, Vinod Shah. After a brutal fight that leaves one of Keeley’s bodyguards dead, Ray strangles him to death with a plastic bag.