Reggie is a turkey who has always feared Thanksgiving because turkeys have always been on the menu, but his incessant attempts to warn his flock have made him an outcast. When the other turkeys finally realize what is happening, they thoughtlessly throw Reggie outside in an attempt to save themselves. To his surprise, he is named the “pardoned turkey” by the President of the United States and is subsequently taken to Camp David. Although initially hesitant, Reggie soon eases into a routine of doing nothing but enjoying pizza from the “Pizza Dude” and watching Mexican telenovelas.
Reggie is kidnapped by Jake, a member of the Turkey Freedom Front, who tells him that “The Great Turkey” told him to find Reggie and take him back to the first Thanksgiving with him to take turkeys off the menu. They steal a time machine controlled by an A.I. named S.T.E.V.E. (Space Time Exploration Vehicle Envoy) from a Government facility. Jake instructs S.T.E.V.E. to time-travel back to the same day in 1621, three days before the first Thanksgiving. Once there, they are ambushed by colonial hunters led by Myles Standish, but they are quickly rescued by native turkeys led by Chief Broadbeak and his two children, Ranger and Jenny.
Broadbeak explains that the turkeys in the area have been forced underground since the settlers came and that they cannot risk fighting back without the settlers taking them. The next day, Broadbeak orders Jake and Ranger to spy on the settlers while Reggie and Jenny spring all the humans’ hunting traps. Despite initial hostility, Ranger and Jake find out that the settlers have already begun preparations for Thanksgiving and where they keep their weapons.