Writer Yudi (Saif Ali Khan) wrote a hit book five and a half years ago but he is still living life king-size in Los Angeles, enjoying fame and affairs, avoiding commitment, doing no work, partying with his miserably married friend Montu (Ranvir Shorey) or having conversations with his fat, bearded inner voice brother Yogi (also Saif). Suddenly, Yudi’s money runs out and his publishers dump him for hit romance novelist Aanchal (Ileana D’Cruz), visiting from Mumbai.
The only work Yudi now gets is from Bollywood single-screen superstar Armaan (Govinda) who insists he copies Hollywood films and writes a multiplex-style romedy, a mix of romance and comedy. Meanwhile, Yudi’s dentist and once-girlfriend Vishakha (Kalki Koechlin) is pursuing him obsessively, even loading videos of him singing in the shower on her laptop, forcing Yudi and Montu to break into her home when she’s away. On top of this, Yudi’s got severe writer’s block, stopping him from finishing any work.
Running away from it all, Yudi tries to charm Aanchal but she’s commitment-averse too. However, she gradually warms up to him, escorting him to Armaan’s party, trying to help Yudi write, even agreeing to take a road trip with him to her book reading in San Francisco.
Eventually reaching San Francisco, the couple is forced to share a hotel room – and agreeing to keep it simple and commitment-free, they end up making love. Their relationship grows funnier – on Aanchal’s last night in LA, they argue over dinner, Yudi throws her phone into a vase while she douses him with water – but neither expresses anything more than a sense of light fun. It’s only when Yudi’s ex-girlfriend Divya (Priety Zinta), having argued with her husband and visiting Yudi with her kids, tells him he loves Aanchal that he admits it to himself.