Susan Cooper is a 40-year-old, single, desk-bound CIA employee who remotely assists her partner, field agent Bradley Fine, on a mission. Fine accidentally kills arms dealer Tihomir Boyanov, failing to learn the location of a suitcase nuke from him. Susan uncovers evidence that Rayna, Boyanov’s daughter, has contacted terrorist middle man Sergio De Luca, so Fine infiltrates her home. Rayna shoots Fine dead, while Susan watches helplessly online. Rayna then reveals that she knows the identities of the agency’s top agents, including Rick Ford and Karen Walker. Susan, once a top trainee agent but now unknown, volunteers to track her. When her boss, Elaine Crocker, reluctantly agrees, the ultra macho Ford quits in disgust.
With her best friend Nancy providing remote intelligence, Susan goes to Paris. Ford shows up and warns her she will fail because of her inexperience. Susan discovers that De Luca’s office has burned down, but finds a photo of a man standing next to the fire. Ford appears, argues with Susan again and leaves. Susan sees the man from the photo switch Ford’s backpack with one containing a bomb. Susan warns Ford in time during a Verka Serduchka concert and then pursues the man, accidentally killing him during the ensuing fight. She finds proof, on his body, that De Luca is going to Rome.
In Rome, Susan meets her contact Aldo. She follows De Luca into a casino, where she saves Rayna’s life. Rayna invites Susan into her inner circle, taking her by private jet to Budapest. In mid-flight, the steward kills Rayna’s crew, but Susan subdues him. Rayna believes Susan to be a CIA agent, but Susan convinces her that she was hired by her father to protect her.